Myeloma by Jayesh Mehta, Seema Singhal

By Jayesh Mehta, Seema Singhal

With contributions from foreign specialists, Myeloma presents a entire assessment of a number of myeloma and comparable plasma-cell problems. It examines the molecular and organic heritage of those illnesses, in addition to their scientific facets and investigations, and advancements in treatment. Containing a hundred and fifty colour illustrations, charts, and graphs, the publication summarizes useful functions of cytogenetic reviews in plasma-cell dyscrasias, covers the pathology of myeloma bone affliction, discusses the present methods of assessing skeletal involvement, and highlights using new biophosphonates. this article is a pragmatic reference for hematologists, oncologists, and researchers.

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57. 58. 59. 60. 61. 62. proliferative syndrome and autoimmunity. Science 1995; 268: 1347–9. Fisher GH, Rosenberg FJ, Straus SE et al. Dominant interfering Fas gene mutations impair apoptosis in a human autoimmune lymphoproliferative syndrome. Cell 1995; 81: 935–46. Takahashi T, Tanaka M, Brannan CI et al. Generalized lymphoproliferative disease in mice, caused by a point mutation in the Fas ligand. Cell 1994; 76: 969–76. Watanabe-Fukunaga R, Brannan CI, Copeland NG et al. Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis.

Kaiser U, Auerbach B, Oldenburg M. The neural cell adhesion molecule NCAM in multiple myeloma. Leuk Lymphoma 1996; 20: 389–95. 11. Van Riet I, De Waele M, Remels L et al. Expression of cytoadhesion molecules (Cd56, Cd54, Cd18 and Cd29) by myeloma plasma cells. Br J Haematol 1991; 79: 421–7. 12. Van Camp B, Durie BG, Spier C et al. Plasma cells in multiple myeloma express a natural killer cellassociated antigen: Cd56 (Nkh-1; Leu-19). Blood 1990; 76: 377–82. PLASMA CELLS AND IMMUNOGLOBULINS 21 13.

The figure shows just some of the proteins encoded by genes that have been implicated in the molecular pathogenesis of myeloma. functions, thus exemplifying the complexity of rational drug design. Further understanding of the transformation process and the pathways involved in malignant progression is essential to the development of effective therapeutic agents. 2. 3. REFERENCES 4. 1. Pope B, Brown R, Luo XF, et al. Disease progression in patients with multiple myeloma is associated with a concurrent alteration in the expression of both oncogenes and tumor suppressor genes and can be monitored by the oncoprotein phenotype.

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