By Wojciech Gorczyca
This Atlas is a necessary advisor to either the analysis and differential analysis of neoplastic hematopathologies, in response to particular parameters. it is going to be a useful reference for all working towards hematologists, oncologists and pathologists. Atlas of Differential prognosis in Neoplastic Hematopathology, moment variation discusses: simple scientific info prognostic info morphologic info phenotypic facts together with over six hundred colour illustrations, Atlas of Differential analysis in Neoplastic Hematopathology, moment version is greatly referenced and up-to-date. masking neoplastic hematopathology, with an emphasis at the differential prognosis, a variety of tables summarize the phenotypic profiles of the commonest hematologic tumors, for the training hematologist, oncologist and pathologist. NEW TO the second one version: A multimethodologic method of neoplastic hematopathology New and considerably up to date sections on differential prognosis and morphology, chromosomal and genetic adjustments, and localization
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Extra info for An Atlas of Differential Diagnosis in Neoplastic Hematopathology
28F). 28G) have scanty cytoplasm, fine chromatin, and inconspicuous nucleoli. Occasional cases of precursor T-lymphoblastic lymphoma/leukemia (and less often B-ALL) have elongated cytoplasm at one pole of the cell, giving a ‘hand-mirror’ appearance to the blast cells. 28H) resemble lymphoblasts or myeloblasts. They are negative for MPO and NSE, and are positive for CD4 and CD56. 29 C Atypical megakaryocytes (MDS) E Reed–Sternberg cell (Hodgkin lymphoma) G B F Histiocytes (hematophagocytic syndrome) H Immature megakaryocytes (AML-M7) Osteoclast (reactive process with bone remodeling) I Cytologic features in bone marrow aspirate – megakaryocytes (see text for details).
H) Neuroblastoma. (I) Spindle cell sarcoma (GIST). (J) Alveolar rhabdomyosarcoma with complex hyperdiploid karyotype. 43 Adult T-cell leukemia/lymphoma I Erythroblastosis (MDS) L Leukoerythroblastosis with thrombocytosis (ET) N Plasma cell leukemia Sezary’s syndrome F K Erythroblastosis fetalis Hairy cell leukemia Neutrophilia (CML) O Cancer cells (breast carcinoma in ‘leukemic phase’) Myeloblasts with erythrophagocytosis (AML) Q Cytologic features in blood (see text for details). 44 D Benign spleen – histology.
E) Burkitt lymphoma. (F) Plasmablastic lymphoma. (G) Plasmacytoid dendritic cell. (H) EMT. 22H). BONE MARROW Normal structure and hematopoiesis In the adult bone marrow occupies the medullary spaces of large bones such as the femur, hip, sternum, and humerus. The marrow cellularity changes with age and can be roughly estimated as (100 − age)% (100% at birth, 50% in a 50 year old, and 10–20% in an 80 year old). 18 Lymph node. Differential diagnosis – clear cell infiltrate. (A) PTLU, signet-ring cell variant.