ABC of clinical haematology by Drew Provan

By Drew Provan

This ABC has demonstrated itself as a well-liked advent to medical Haematology, proper either for postgraduate scholars and first care practitioners. Now in its 3rd variation, the ABC of medical Haematology has been completely revised, that includes the newest remedies for leukemia, antithrombotics and medication for lymphoma and overlaying the most recent advances in hematology and bone marrow transplantation.

With each one bankruptcy written through experts of their respective fields, this can be a terrific simple textual content for basic perform and health facility employees with sufferers who've blood similar difficulties, particularly GPs, hematology nurses, junior medical professionals, hematologists, and trainees in hematology.

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Interferon-α has also been used and is particularly useful in pregnancy. Idiopathic myelofibrosis The main features are bone marrow fibrosis, extramedullary haemopoiesis (production of blood cells in organs other than the bone marrow), splenomegaly and a leucoerythroblastic blood picture (immature red and white cells in the blood) (Fig. 6). Good evidence exists that the fibroblast proliferation is secondary and not part of the clonal process. In some patients, the fibrosis is accompanied by new bone formation (osteomyelosclerosis).

Presentation may be at any age, but the peak incidence is at 50–70 years, with a slight male predominance. This leukaemia is very rare in children. Because the disease evolves very slowly and ‘routine’ blood counts are carried out increasingly frequently, today, up to 50% of patients are diagnosed before showing any symptoms. Most cases of CML occur sporadically. The only known predisposing factor is irradiation as shown by studies of Japanese survivors of the atomic bombs and in patients who have received radiotherapy for ankylosing spondylitis and various neoplastic conditions.

7 Bone marrow aspirate showing increased megakarocytes in immune thrombocytopenia. 2 Disorders with increased consumption of platelets • Disorders with immune mechanism • Autoimmune: idiopathic thrombocytopenic purpura • Alloimmune: post-transfusion purpura, neonatal alloimmune thrombocytopenia • Infection-associated: infectious mononucleosis, HIV, malaria • Drug-induced: heparin, penicillin, quinine, sulphonamides, rifampicin • Thrombotic thrombocytopenic purpura/haemolytic uraemic syndrome • Hypersplenism and splenomegaly • Disseminated intravascular coagulation • Massive transfusion Post-transfusion purpura Post-transfuson purpura is a rare complication of blood transfusion.

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